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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SETD1A
All Species:
7.88
Human Site:
Y412
Identified Species:
13.33
UniProt:
O15047
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15047
NP_055527.1
1707
186034
Y412
F
P
P
S
Y
T
S
Y
L
P
P
E
P
S
R
Chimpanzee
Pan troglodytes
XP_523492
1707
185692
Y412
F
P
P
S
Y
T
S
Y
L
P
P
E
P
S
R
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_848999
1330
145541
H156
K
E
T
V
K
N
L
H
L
T
S
V
M
G
N
Cat
Felis silvestris
Mouse
Mus musculus
Q8CFT2
1985
215333
R420
S
R
D
S
G
E
F
R
R
A
P
A
P
P
P
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506028
1287
141359
F113
I
L
P
P
L
P
P
F
H
P
G
M
F
P
M
Chicken
Gallus gallus
Q5F3P8
2008
223067
T471
S
A
P
S
F
S
Q
T
P
E
R
S
E
T
P
Frog
Xenopus laevis
Q66J90
1938
216239
E438
K
L
V
K
E
K
P
E
E
P
P
P
P
E
P
Zebra Danio
Brachydanio rerio
Q1LY77
1844
204122
P457
V
R
D
R
P
T
T
P
P
I
P
E
P
P
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001015221
1641
188364
S414
R
S
S
N
T
I
S
S
Y
Y
S
A
S
S
L
Honey Bee
Apis mellifera
XP_395451
1406
159180
K232
T
T
E
K
K
P
E
K
K
I
E
K
E
I
K
Nematode Worm
Caenorhab. elegans
Q18221
1507
171664
N333
S
V
Q
L
P
Y
Y
N
N
I
Q
P
S
S
S
Sea Urchin
Strong. purpuratus
XP_791552
1963
220543
F469
D
D
R
G
S
K
R
F
D
D
D
R
G
S
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P38827
1080
123894
Red Bread Mold
Neurospora crassa
Q8X0S9
1313
145607
S139
R
N
S
H
T
H
N
S
T
T
P
L
T
T
A
Conservation
Percent
Protein Identity:
100
99.5
N.A.
73.2
N.A.
37
N.A.
N.A.
27.7
34.5
34.1
36.7
N.A.
25.6
24.6
20.9
23.7
Protein Similarity:
100
99.5
N.A.
74.7
N.A.
49.5
N.A.
N.A.
38.7
47.5
48.6
50.7
N.A.
41.3
39.6
35.8
39.2
P-Site Identity:
100
100
N.A.
6.6
N.A.
20
N.A.
N.A.
13.3
13.3
20
26.6
N.A.
13.3
0
6.6
6.6
P-Site Similarity:
100
100
N.A.
13.3
N.A.
20
N.A.
N.A.
20
33.3
20
33.3
N.A.
20
13.3
6.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
21.7
22.2
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
33.8
36.5
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
0
20
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
0
0
0
0
8
0
15
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
8
15
0
0
0
0
0
8
8
8
0
0
0
0
% D
% Glu:
0
8
8
0
8
8
8
8
8
8
8
22
15
8
0
% E
% Phe:
15
0
0
0
8
0
8
15
0
0
0
0
8
0
0
% F
% Gly:
0
0
0
8
8
0
0
0
0
0
8
0
8
8
0
% G
% His:
0
0
0
8
0
8
0
8
8
0
0
0
0
0
0
% H
% Ile:
8
0
0
0
0
8
0
0
0
22
0
0
0
8
0
% I
% Lys:
15
0
0
15
15
15
0
8
8
0
0
8
0
0
15
% K
% Leu:
0
15
0
8
8
0
8
0
22
0
0
8
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
8
8
0
8
% M
% Asn:
0
8
0
8
0
8
8
8
8
0
0
0
0
0
8
% N
% Pro:
0
15
29
8
15
15
15
8
15
29
43
15
36
22
29
% P
% Gln:
0
0
8
0
0
0
8
0
0
0
8
0
0
0
0
% Q
% Arg:
15
15
8
8
0
0
8
8
8
0
8
8
0
0
15
% R
% Ser:
22
8
15
29
8
8
22
15
0
0
15
8
15
36
8
% S
% Thr:
8
8
8
0
15
22
8
8
8
15
0
0
8
15
0
% T
% Val:
8
8
8
8
0
0
0
0
0
0
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
15
8
8
15
8
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _